Gentle Cell Sorting Advancing
ALS Research

We'd like to share a recent blog post on how NanoCellect’s WOLF® Cell Sorter is helping advance ALS research: Read here.

Researchers using iPSC-derived neurons and glia for ALS models have found that WOLF’s gentle, low-pressure sorting preserves fragile cells’ viability and function—unlike traditional droplet sorters. This has enabled new insights into both common and rare ALS mutations by keeping delicate neuronal populations intact for downstream studies.

This gentle sorting capability is especially critical when studying ALS, a neurodegenerative disease marked by motor neuron degradation, where even subtle mechanical stress can skew results.

The post details two significant research applications:

• A 2024 study in Human Molecular Genetics exploring two prevalent ALS mutations—SOD1 and C9ORF72—using iPSC-derived models to reveal common pathological pathways.

• A project at Case Western Reserve University investigating a rare VAPB mutation linked to mitochondrial–ER communication breakdowns.

Both studies demonstrate how the WOLF's gentle sorting preserves delicate cell states while enabling separation of mixed populations—facilitating deeper insights into shared neurodegenerative mechanisms such as mitochondrial dysfunction and glia-neuron stress responses

Let's discuss how gentle cell sorting can empower
your research!